Publications
Some Recent Papers
1. Halder, G., Callaerts, P. and Gehring, W.J. (1995). Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 267, 1788-1792.
2. Gehring, W.J. & Wehner, R. (1995). Heat shock protein synthesis and thermo-tolerance in Cataglyphis, an ant from the Sahara desert. Proc. Natl. Acad. Sci. USA 92, 2994-2998.
3. Halder, G., Callaerts, P. and Gehring, W.J. (1995). New perspectives on eye evolution. Current Opinion in Genetics & Development 5, 602-609.
4. Wehner, R. and Gehring, W.J. (1995). Zoologie. 23. Auflage. Thieme Verlag, Stuttgart, p. 849.
5. Gehring, W.J. (1995). De la mouche à l'homme, un même supergène pour l'oeil. La Recherche 280, 58-64.
6. Hirth, F., Therianos, S., Loop, T., Gehring, W.J., Reichert, H. and Furukubu-Tokunaga, K. (1995). Developmental defects in brain segmentation caused by mutations of the homeobox genes orthodenticle and empty spiracles in Drosophila. Neuron 15, 769-778.
7. Rivera-Pomar, R., Niessing, D., Schmidt-Ott, U., Gehring, W.J. and Jäckle, H. (1996). RNA binding and translational suppression by bicoid. Nature 379, 747-749.
8. Gehring, W.J. (1996). The master control gene for morphogenesis and evolution of the eye. Genes to Cells 1, 11-15.
9. Loosli, F., Kmita-Cunisse, M. and Gehring, W.J. (1996). Isolation of a Pax-6 homolog from the ribbonworm Lineus sanguineus. Proc. Natl. Acad. Sci. USA 93, 2658-2663.
10. Montagne, J., Groppe, J., Guillemin, K., Krasnow, M.A., Gehring, W.J. and Affolter, M. (1996). The Drosophila Serum Response Factor gene is required for the formation of intervein tissue of the wing and is allelic to blistered. Development 122, 2589-2597.
11. Haerry, T.E. and Gehring, W.J. (1996). Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can function as an enhancer element in Drosophila. Proc. Natl. Acad. Sci. USA 93, 13884-13889.
12. Glardon, S., Callaerts, P., Halder, G. and Gehring, W.J. (1997). Conservation of Pax-6 in a lower chordate, the ascidian Phallusia mammillata. Development 124, 817-825.
13. Niimi, T. and Gehring, W.J. (1997). eyeless/Pax-6 and eye morphogenesis. Japanese J. of Experimental Medicine 15/4, 151-157.
14. Tomarev S. I., Callaerts P., Kos, L., Zinovieva, R., Halder, G., Gehring, W. and Piatigorsky, J. (1997). Squid Pax-6 and eye development. Proc. Natl. Acad. Sci. USA 94, 2421-2426.
15. Callaerts, P., Halder, G. and Gehring, W.J. (1997). Pax-6 in development and evolution. Annu. Rev. Neurosci. 20, 483-532.
16. Haerry, T.E. and Gehring, W.J. (1997). A conserved cluster of homeodomain binding sites in the mouse Hoxa-4 intron functions in Drosophila embryos as an enhancer that is directly regulated by Ultrabithorax. Develop. Biol. 186, 1-15.
17. Keegan, L.P., Haerry, T.E., Crotty, D.A., Packer, A.I., Wolgemuth, D.J. and Gehring, W.J. (1997). A sequence conserved in vertebrate Hox gene introns functions as an enhancer regulated by posterior homeotic genes in Drosophila imaginal discs. Mech. Dev. 63, 145-157.
18. Yamamoto, Y., Girard, F., Bello, B., Affolter, M. and Gehring, W.J. (1997). The cramped gene of Drosophila is a member of the Polycomb-group, and interacts with mus209, the gene encoding proliferating cell nuclear antigen. Development 124, 3385-3394.
19. Gehring, W.J. (1997). The discovery of the homeobox in retrospective. IX Taniguchi Symposium on Developmental Biology "Developmental Biology in Half a Century", Kyoto/Japan
20. Gehring, W.J. (1997). Die genetische Steuerung von Morphogenese und Evolution der Augen. Nova Acta Leopoldina 76, 303-312.
21. Gehring, W.J. (1998). Die Entwicklung and Evolution des Auges: Ein Blick in die Werkstatt der Gene. in Reden und Gedenkworte 27. Orden pour le Mérite für Wissenschaften und Künste, Gerlingen, pp. 49-60.
22. Eggert, T., Hauck, B., Hildebrandt, N., Gehring, W.J. and Walldorf, U. (1998). Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and its possible role in brain and eye development. Proc. Natl. Acad. Sci. USA 95, 2343-2348.
23. Kmita-Cunisse, M., Loosli, F., Bièrne, J. and Gehring, W.J. (1998). Homeobox genes in the ribbonworm Lineus sanguineus: Evolutionary implications. Proc. Natl. Acad.Sci. USA 95, 3030-3035.
24. Girard, F., Bello, B., Laemmli, U.K. and Gehring, W.J. (1998). In vivo analysis of Scaffold-associated regions in Drosophila: a synthetic high-affinity SAR binding protein suppresses position effect variegation. EMBO J. 17, 2079-2085.
25. Halder, G., Callaerts, P., Flister, S., Walldorf, U., Kloter, U. and Gehring, W.J. (1998). Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development. Development 125, 2181-2191).
26. Bello, B., Resendez-Perez, D. and Gehring, W.J. (1998). Spatial and temporal targeting of gene expression in Drosophila by means of a tetracycline-dependent transactivator system. Development 125, 2193-2202.
27. Glardon, S., Holland, L.Z., Gehring, W.J. and Holland N.D. (1998). Isolation and developmental expression of the amphioxus Pax-6 gene (AmphiPax-6): insights into eye and photoreceptor evolution. Development 125, 2701-2710.
28. Leuzinger, S. Hirth, F., Gerlich, D., Acampora, D., Simeone, A., Gehring, W.J., Finkelstein, R., Furukubo-Tokunaga, K. and Reichert, H. (1998). Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila. Development 125, 1703-1710.
29. Callerts, P., Munoz-Marmol, A.M., Glardon, S., Castillo, E., Sun, H., Li, W.-H., Gehring, W.J. and Salo, E. (1999). Isolation and expression of a Pax-6 gene I the regenerating and intact Planarian Dugesia(G)tigrina. Proc. Natl. Acad. Sci. USA 96, 558-563.
30. Hauck, B., Gehring, W. J. and Walldorf, U. (1999). Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila. Proc. Natl. Acad. Sci USA 96, 564-569.
31. Janssens, H. and Gehring, W.J. (1999). Isolation and Characteization of drosocrystallin, a Lens Crystallin Gene of Drosophila melanogaster. Dev. Biol. 207, 204-214.
32. Czerny, T., Halder, G., Callaerts, P., Kloter, U., Souabni, A. Gehring, W.J. and Busslinger, M. (1999). Twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development. Mol. Cell 3, 297-307.
33. Niimi, T., Seimiya, M., Kloter, U., Flister, S. and Gehring, W.J. (1999). Direct regulatory interaction of the eyeless protein with an eye-specific enhancer in the sine oculis gene during eye induction in Drosophila. Development 126, 2253-2260.
34. Gehring, W.J. and Ikeo, K. (1999). Pax 6. Mastering eye morphogenesis and eye evolution. Trends in Genetics 15, 371-377.
35. Tarpin, M., Gehring W.J. and Biérne J. (1999). Reverse homeosis in homeotically reconstructed ribbonworms. Proc. Natl. Acad. Sci. USA 96, 11900-11903.
36. Gröger, H., Callaerts, P., Gehring, W.J., Schmid, V. (1999). Gene Duplication and Recruitment of a Specific Tropomyosin into Striated Muscle Cells in the Jellyfish Podocoryne carnea. Journal of Experimental Zoology (Mol Dev Evol) 285, 378-386.
37. Kurata, S., Go, M..J., Artavanis-Tsakonas, S. and Gehring, W.J. (2000). Notch signalling and the determination of appendage identity. Proc. Natl. Acad. Sci. USA 97, 2117-2122.
38. Kurusu, M., Nagao, T., Walldorf, U., Flister, S., Gehring. W.J. and, Furukubo-Tokunaga, K. (2000). Genetic control of development of the mushroom bodies, the associative learning centers in the Drosopila brain, by the eyeless, twin of eyeless, and dachshund genes. Proc. Natl. Acad. Sci. USA 97, 2140-2144.
39. Engels, A., Reichert, H., Gehring, W.J. and Gärtner, W. (2000). Functional expression of a locust visual pigment in transgenic Drosophila melanogaster. Eur. J. Biochem. 267, 1917-1922.
40. Seimiya, M. and Gehring, W. (2000). The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism. Development 127, 1879-1886.
41. Miller, D.J., Hayward, D.C., Reece-Hoyes, J., Scholten, I., Catmull, J., Gehring, W.J., Callaerts, P., Larsen, J.E. and Ball, E. (2000). Pax gene diversity in the basal cnidarian Acropora millepora (Cnideria; Anthozoa): Implications for the evolution of the Pax gene family. Proc. Natl. Acad. Sci. USA 97, 4475-4480.
42. Pineda, D, Gonzalez, J., Callaerts, P., Ikeo, K., Gehring, W.J. and Salo, E. (2000). Searching for the prototypic eye genetic network: sine oculis is essential for eye regeneration in planarians. Proc. Natl. Acad. Sci. USA 97, 4525-4529.
43. Berry, M. and Gehring, W.J. (2000). Phosphorylation status of the SCR homeodomain determines its functional activity: essential role for protein phosphatase 2A,B'. EMBO J. 19, 2946-2957.
Some Earlier Major Papers
1. 1967 Clonal analysis of determination dynamics in cultures of imaginal discs in Drosophila melanogaster. Develop. Biol. 16
2. 1984 A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans. (with Garber, R. L. and others) Cell 37
3. 1985 Homeotic genes, the homeobox, and the genetic control of development. Cold Spring Harb. Symp. Quant. Biol. 50
4. 1987 Homeoboxes in the study of development. Science 236
5. 1994 Homology of the eyeless gene in Drosophila to the Small eye gene in mice and Aniridia in humans. (with Walldorf, U. and others) Science 265
6. 1995 Introduction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. (with Georg, H. and others) Science 267
Books
1 . Gehring, W.J. (1998). Master Control Genes in Development and Evolution: The Homeobox Story. Yale University Press New Haven, USA.